Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 835)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0958389	0.1175345	0.4239897
Weighted median	23	0.0209928	0.0626031	0.7373753
Inverse variance weighted	23	-0.0362117	0.0464482	0.4356180
Simple mode	23	0.0532989	0.1116973	0.6379456
Weighted mode	23	0.0744853	0.0958262	0.4452627

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.11575	21	0.1112502
Inverse variance weighted	31.18141	22	0.0924628

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0081093	0.0066437	0.2357653

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000971	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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