Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 834)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0934580	0.0998206	0.3597823
Weighted median	23	0.0499516	0.0563773	0.3756043
Inverse variance weighted	23	0.0621989	0.0390156	0.1108898
Simple mode	23	0.0231918	0.0919376	0.8031853
Weighted mode	23	0.0468878	0.0669206	0.4908670

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.42891	21	0.7450890
Inverse variance weighted	16.54466	22	0.7879666

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019196	0.0056423	0.7370729

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005783	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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