Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 833)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0559092	0.1105934	0.6184455
Weighted median	23	-0.0514806	0.0563926	0.3612967
Inverse variance weighted	23	0.0086482	0.0426348	0.8392569
Simple mode	23	0.0012165	0.1013352	0.9905299
Weighted mode	23	-0.0587160	0.0712380	0.4186599

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.77773	21	0.2150512
Inverse variance weighted	26.27143	22	0.2402109

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039645	0.0062513	0.5328077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007976	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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