Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 832)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1132156	0.0998205	0.2694957
Weighted median	23	-0.0206403	0.0549607	0.7072538
Inverse variance weighted	23	-0.0000602	0.0390156	0.9987694
Simple mode	23	-0.0376612	0.0903789	0.6809328
Weighted mode	23	-0.0860506	0.0681710	0.2200673

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.41714	21	0.7457748
Inverse variance weighted	17.93388	22	0.7099015

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069489	0.0056423	0.231728

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005434	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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