Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 831)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0873507	0.1014145	0.3987884
Weighted median	23	0.0176791	0.0557392	0.7511103
Inverse variance weighted	23	0.0076306	0.0393942	0.8464112
Simple mode	23	0.0293806	0.0945089	0.7588205
Weighted mode	23	0.0204326	0.0644483	0.7542034

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.67614	21	0.4183738
Inverse variance weighted	22.42897	22	0.4345477

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048956	0.0057324	0.4027323

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006808	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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