Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 830)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1216852	0.1194473	0.3199225
Weighted median	23	-0.1219302	0.0609147	0.0453216
Inverse variance weighted	23	-0.0474619	0.0461058	0.3032864
Simple mode	23	-0.0887427	0.1163691	0.4538032
Weighted mode	23	-0.1530630	0.0842900	0.0830387

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.07102	21	0.0905701
Inverse variance weighted	30.72363	22	0.1019109

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045581	0.0067518	0.5069827

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009758	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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