Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 83)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0787757	0.0998209	0.4388320
Weighted median	23	0.0761168	0.0564366	0.1774287
Inverse variance weighted	23	0.0683717	0.0390154	0.0797005
Simple mode	23	0.0765220	0.0919535	0.4142489
Weighted mode	23	0.0603764	0.0643750	0.3584862

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.46414	21	0.6194724
Inverse variance weighted	18.47697	22	0.6773642

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006389	0.0056424	0.9109203

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006529	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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