Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 829)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0370450	0.1480226	0.8048140
Weighted median	23	-0.0437084	0.0652371	0.5028617
Inverse variance weighted	23	0.0172379	0.0565543	0.7605162
Simple mode	23	-0.0278371	0.1249152	0.8257095
Weighted mode	23	-0.0584246	0.0847396	0.4977418

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.18067	21	0.0012090
Inverse variance weighted	46.22714	22	0.0018487

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012164	0.008367	0.8858007

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014066	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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