Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 828)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0011346	0.0998210	0.9910385
Weighted median	23	-0.0613496	0.0544245	0.2596395
Inverse variance weighted	23	-0.0001615	0.0390158	0.9966978
Simple mode	23	-0.1110364	0.0879304	0.2198910
Weighted mode	23	-0.0707627	0.0672000	0.3037617

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.35684	21	0.8956118
Inverse variance weighted	13.35704	22	0.9227230

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-7.96e-05	0.0056424	0.9888786

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004048	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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