Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 827)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0354373	0.0998203	0.7261223
Weighted median	23	0.0382315	0.0571249	0.5033284
Inverse variance weighted	23	-0.0164683	0.0390157	0.6729565
Simple mode	23	-0.0931602	0.0999766	0.3615439
Weighted mode	23	0.0595612	0.0662168	0.3781333

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.22366	21	0.7569557
Inverse variance weighted	16.54281	22	0.7880644

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031875	0.0056423	0.5781074

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005067	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8