Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 826)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0382944	0.1079627	0.7263516
Weighted median	23	-0.0625529	0.0606855	0.3026475
Inverse variance weighted	23	-0.0612388	0.0412806	0.1379478
Simple mode	23	-0.0290558	0.1032516	0.7810279
Weighted mode	23	-0.0895474	0.0771723	0.2583409

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.56684	21	0.2664113
Inverse variance weighted	24.62921	22	0.3151328

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001409	0.0061027	0.8196353

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000821	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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