Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 825)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0492361	0.1126478	0.6665150
Weighted median	23	-0.0147991	0.0587371	0.8010756
Inverse variance weighted	23	-0.0344410	0.0430378	0.4235653
Simple mode	23	-0.0120346	0.0979596	0.9033396
Weighted mode	23	-0.0310517	0.0652481	0.6388356

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.74405	21	0.1794866
Inverse variance weighted	26.76998	22	0.2200935

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009086	0.0063674	0.8878954

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008348	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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