Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 824)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0059063	0.0998202	0.9533763
Weighted median	23	-0.0760287	0.0567014	0.1799656
Inverse variance weighted	23	-0.0813614	0.0390155	0.0370364
Simple mode	23	-0.1472796	0.0948832	0.1348775
Weighted mode	23	-0.0594226	0.0721912	0.4192683

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.23444	21	0.5064582
Inverse variance weighted	21.13657	22	0.5123121

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0053591	0.0056423	0.3530148

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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