Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 823)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0356020 0.1049066 0.7377026
Weighted median 23 -0.0181054 0.0561906 0.7472903
Inverse variance weighted 23 -0.0199923 0.0403757 0.6204904
Simple mode 23 -0.0177448 0.1069861 0.8697814
Weighted mode 23 -0.0563134 0.0636117 0.3855858

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.19472 21 0.3336847
Inverse variance weighted 23.56084 22 0.3706626

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0034141 0.0059299 0.5709099

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007219 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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