Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 822)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0846496	0.0998207	0.4059913
Weighted median	23	0.0519575	0.0550204	0.3450003
Inverse variance weighted	23	0.0206032	0.0390157	0.5974472
Simple mode	23	0.0663372	0.0865612	0.4516064
Weighted mode	23	0.0526295	0.0553533	0.3520386

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.9923	21	0.711573
Inverse variance weighted	17.4782	22	0.736439

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039331	0.0056424	0.4934075

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005381	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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