Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 821)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1443018	0.1101323	0.2042597
Weighted median	23	0.1099145	0.0565862	0.0520855
Inverse variance weighted	23	0.0387832	0.0431279	0.3685151
Simple mode	23	0.0947203	0.1001071	0.3543295
Weighted mode	23	0.1157212	0.0599665	0.0666308

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.56349	21	0.2235841
Inverse variance weighted	26.88244	22	0.2157256

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064799	0.0062252	0.3097526

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008445	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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