Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 820)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0582707	0.1105520	0.6036566
Weighted median	23	-0.0034986	0.0540270	0.9483678
Inverse variance weighted	23	-0.0198355	0.0428046	0.6430798
Simple mode	23	0.0101632	0.0851480	0.9060737
Weighted mode	23	-0.0000536	0.0608118	0.9993043

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.75780	21	0.2158352
Inverse variance weighted	26.48044	22	0.2316267

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047965	0.0062489	0.4512875

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008102	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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