Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 82)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0241267	0.0998207	0.8113569
Weighted median	23	0.0300595	0.0543045	0.5798958
Inverse variance weighted	23	0.0511355	0.0390157	0.1899795
Simple mode	23	0.0944777	0.0982993	0.3469361
Weighted mode	23	-0.0138268	0.0765148	0.8582519

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.884741	21	0.9803698
Inverse variance weighted	9.971151	22	0.9865644

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016586	0.0056424	0.7716769

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003542	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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