Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 819)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0487951	0.0998186	0.6300227
Weighted median	23	0.0467798	0.0615282	0.4470763
Inverse variance weighted	23	0.0447196	0.0390151	0.2517076
Simple mode	23	0.0670741	0.1224618	0.5894022
Weighted mode	23	0.0921174	0.1202538	0.4518029

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.10141	21	0.5148461
Inverse variance weighted	21.13736	22	0.5122636

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0057428	0.0056423	0.3203502

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006803	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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