Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 818)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1716201	0.1127110	0.1427619
Weighted median	23	-0.0176189	0.0564483	0.7549463
Inverse variance weighted	23	0.0079444	0.0460086	0.8629099
Simple mode	23	-0.0372107	0.0912756	0.6874531
Weighted mode	23	-0.0245597	0.0567305	0.6692887

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.77393	21	0.1784621
Inverse variance weighted	30.59336	22	0.1047414

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0110269	0.0063709	0.0981519

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009282	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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