Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 817)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0769419	0.1139487	0.5068952
Weighted median	23	0.0179901	0.0588968	0.7600221
Inverse variance weighted	23	0.0295457	0.0445689	0.5073812
Simple mode	23	0.0193404	0.1010314	0.8499450
Weighted mode	23	0.0193404	0.0706057	0.7867008

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.36551	21	0.1590800
Inverse variance weighted	28.70877	22	0.1533648

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065394	0.0064409	0.3215244

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008873	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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