Two sample MR report


Telomere_length against rfMRI connectivity (ICA100 edge 816)

Date: 22 April, 2022


Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0715397 0.0998201 0.4814631
Weighted median 23 0.0488890 0.0572096 0.3927945
Inverse variance weighted 23 0.0030223 0.0390155 0.9382537
Simple mode 23 0.0380326 0.0940461 0.6898207
Weighted mode 23 0.0641904 0.0737132 0.3932598

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 16.02946 21 0.7679937
Inverse variance weighted 16.58557 22 0.7858005

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0042077 0.0056423 0.4640962

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0005028 TRUE 0

Note - R2 values are approximate


Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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