Two sample MR report
Telomere_length against rfMRI connectivity (ICA100 edge 816)
Date: 22 April, 2022
Results from two sample MR:
| method |
nsnp |
b |
se |
pval |
| MR Egger |
23 |
0.0715397 |
0.0998201 |
0.4814631 |
| Weighted median |
23 |
0.0488890 |
0.0572096 |
0.3927945 |
| Inverse variance weighted |
23 |
0.0030223 |
0.0390155 |
0.9382537 |
| Simple mode |
23 |
0.0380326 |
0.0940461 |
0.6898207 |
| Weighted mode |
23 |
0.0641904 |
0.0737132 |
0.3932598 |
Heterogeneity tests
| method |
Q |
Q_df |
Q_pval |
| MR Egger |
16.02946 |
21 |
0.7679937 |
| Inverse variance weighted |
16.58557 |
22 |
0.7858005 |
Test for directional horizontal pleiotropy
| egger_intercept |
se |
pval |
| -0.0042077 |
0.0056423 |
0.4640962 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure |
snp_r2.outcome |
correct_causal_direction |
steiger_pval |
| 0.0357937 |
0.0005028 |
TRUE |
0 |
Note - R2 values are approximate
Forest plot of single SNP MR

Comparison of results using different MR methods

Funnel plot

Leave-one-out sensitivity analysis
