Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 815)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0742041	0.0998199	0.4654884
Weighted median	23	-0.0336251	0.0582682	0.5638889
Inverse variance weighted	23	-0.0353425	0.0390154	0.3650107
Simple mode	23	-0.0620677	0.1034466	0.5546384
Weighted mode	23	-0.0077162	0.0766667	0.9207429

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.79686	21	0.5341589
Inverse variance weighted	21.21841	22	0.5072772

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067273	0.0056423	0.246448

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006678	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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