Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 814)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.1105750 0.1041111 0.3002585
Weighted median 23 -0.0690721 0.0566804 0.2229866
Inverse variance weighted 23 -0.0155642 0.0406774 0.7019974
Simple mode 23 -0.0561744 0.1128526 0.6235868
Weighted mode 23 -0.0985177 0.0616691 0.1244147

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 22.84524 21 0.3522853
Inverse variance weighted 23.91461 22 0.3517214

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0058347 0.0058849 0.3327473

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007295 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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