Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 813)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0205325	0.1088519	0.8521955
Weighted median	23	0.0471689	0.0642187	0.4626416
Inverse variance weighted	23	0.0337251	0.0415846	0.4173659
Simple mode	23	0.1197659	0.1242365	0.3455159
Weighted mode	23	0.0476655	0.0839781	0.5760574

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.97234	21	0.2483642
Inverse variance weighted	24.99295	22	0.2974118

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008102	0.0061529	0.8964973

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00078	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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