Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 812)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2302637	0.1184608	0.0654410
Weighted median	23	0.1135696	0.0552316	0.0397592
Inverse variance weighted	23	0.0608141	0.0477674	0.2029719
Simple mode	23	0.1282182	0.0960220	0.1954309
Weighted mode	23	0.1153038	0.0639829	0.0852490

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.57644	21	0.1008356
Inverse variance weighted	32.97784	22	0.0621862

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0104059	0.006696	0.1351141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010729	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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