Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 811)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1374291	0.1300686	0.3027030
Weighted median	23	0.0383269	0.0590498	0.5162993
Inverse variance weighted	23	0.0341679	0.0505417	0.4990191
Simple mode	23	0.0409729	0.1071302	0.7057909
Weighted mode	23	0.0291284	0.0655937	0.6613264

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.65601	21	0.0238913
Inverse variance weighted	36.91912	22	0.0241438

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063412	0.0073521	0.3981498

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011419	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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