Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 81)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1090667	0.1082065	0.3249525
Weighted median	23	0.0797278	0.0557968	0.1530340
Inverse variance weighted	23	0.0707210	0.0444117	0.1112959
Simple mode	23	0.0637799	0.0889284	0.4807936
Weighted mode	23	0.0707015	0.0587996	0.2419855

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.67773	21	0.2613915
Inverse variance weighted	28.50685	22	0.1594860

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0110408	0.0061164	0.0854149

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009633	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8