Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 809)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1180561	0.0999628	0.2508057
Weighted median	23	-0.0116524	0.0594307	0.8445572
Inverse variance weighted	23	0.0030528	0.0397162	0.9387301
Simple mode	23	-0.0137955	0.1018419	0.8934801
Weighted mode	23	-0.0165937	0.0666671	0.8057437

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.05996	21	0.4552877
Inverse variance weighted	22.79741	22	0.4132439

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074373	0.0056504	0.2022784

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000691	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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