Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 808)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1678632	0.1070199	0.1317050
Weighted median	23	-0.0070069	0.0594602	0.9061934
Inverse variance weighted	23	-0.0378202	0.0425299	0.3738627
Simple mode	23	-0.0130808	0.0953462	0.8921266
Weighted mode	23	-0.0048594	0.0777950	0.9507571

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.13923	21	0.2863614
Inverse variance weighted	26.14254	22	0.2456125

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007986	0.0060493	0.2009961

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008206	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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