Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 807)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0553501	0.1089077	0.6165900
Weighted median	23	-0.0324175	0.0629374	0.6065000
Inverse variance weighted	23	-0.0440499	0.0416012	0.2896626
Simple mode	23	-0.0482925	0.1242535	0.7012631
Weighted mode	23	-0.0092273	0.0848663	0.9144038

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.99780	21	0.2472596
Inverse variance weighted	25.01292	22	0.2964572

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006939	0.006156	0.9113182

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007966	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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