Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 806)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1675943	0.1086576	0.1379101
Weighted median	23	-0.0785038	0.0566840	0.1660717
Inverse variance weighted	23	-0.0298945	0.0433254	0.4901950
Simple mode	23	0.0483440	0.1101753	0.6650915
Weighted mode	23	-0.0740581	0.0621729	0.2462820

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.88303	21	0.2522658
Inverse variance weighted	27.12913	22	0.2063630

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084561	0.0061418	0.1830745

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008399	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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