Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 805)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1235587	0.0998198	0.2294449
Weighted median	23	-0.0952236	0.0549244	0.0829673
Inverse variance weighted	23	-0.0717901	0.0390154	0.0657611
Simple mode	23	0.0345769	0.0945087	0.7179646
Weighted mode	23	-0.1253069	0.0670768	0.0751238

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.15204	21	0.7610488
Inverse variance weighted	16.46950	22	0.7919211

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031791	0.0056423	0.5791016

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006017	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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