Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 804)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0801992	0.1328841	0.5526216
Weighted median	23	0.0711191	0.0619310	0.2508195
Inverse variance weighted	23	0.0170148	0.0510664	0.7389905
Simple mode	23	-0.1385041	0.1436052	0.3452892
Weighted mode	23	0.1664749	0.0850362	0.0630695

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.21804	21	0.0158893
Inverse variance weighted	37.69098	22	0.0198392

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038802	0.0075113	0.6108477

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011479	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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