Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 803)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0426600	0.0998204	0.6734620
Weighted median	23	0.0655981	0.0573693	0.2528580
Inverse variance weighted	23	-0.0092676	0.0390154	0.8122399
Simple mode	23	0.0437435	0.0919011	0.6387784
Weighted mode	23	0.0644234	0.0684689	0.3569664

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.67889	21	0.6057305
Inverse variance weighted	18.99831	22	0.6454331

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031889	0.0056424	0.577948

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005774	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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