Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 802)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0822097	0.0998191	0.4194301
Weighted median	23	0.0970885	0.0547524	0.0761909
Inverse variance weighted	23	0.0919293	0.0390153	0.0184612
Simple mode	23	0.0947720	0.0911500	0.3097550
Weighted mode	23	0.1089057	0.0642619	0.1042396

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.97148	21	0.7712515
Inverse variance weighted	15.98267	22	0.8167450

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005969	0.0056423	0.916755

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006525	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8