Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 801)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0268770	0.0998213	0.7903639
Weighted median	23	-0.0373431	0.0542436	0.4911806
Inverse variance weighted	23	-0.0286507	0.0390158	0.4627432
Simple mode	23	-0.0306230	0.0873179	0.7291438
Weighted mode	23	-0.0166180	0.0642532	0.7983231

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.40223	21	0.9732022
Inverse variance weighted	10.76746	22	0.9779102

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00341	0.0056424	0.5520874

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003426	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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