Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 800)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0702180	0.1103199	0.5313317
Weighted median	23	-0.0555508	0.0594314	0.3499410
Inverse variance weighted	23	-0.0588531	0.0421411	0.1625420
Simple mode	23	0.0609276	0.1195146	0.6152731
Weighted mode	23	-0.0625953	0.0847691	0.4680637

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.65134	21	0.2200565
Inverse variance weighted	25.66664	22	0.2662697

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006979	0.0062358	0.9119489

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008467	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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