Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 80)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0003834	0.0998210	0.9969713
Weighted median	23	-0.0302298	0.0529868	0.5683274
Inverse variance weighted	23	-0.0072624	0.0390158	0.8523352
Simple mode	23	-0.0363134	0.0839372	0.6694976
Weighted mode	23	-0.0232935	0.0612402	0.7073240

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.96093	21	0.8712715
Inverse variance weighted	13.96654	22	0.9026626

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004224	0.0056424	0.941028

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004243	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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