Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 8)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0510593	0.1063947	0.6362561
Weighted median	23	0.0135256	0.0584027	0.8168544
Inverse variance weighted	23	0.0543426	0.0406301	0.1810604
Simple mode	23	0.0299947	0.0937085	0.7519235
Weighted mode	23	-0.0223454	0.0738336	0.7650035

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.85751	21	0.3000137
Inverse variance weighted	23.85879	22	0.3546749

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002016	0.006014	0.9735709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007817	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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