Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 799)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0163410	0.0998193	0.8715277
Weighted median	23	-0.0324284	0.0627670	0.6054024
Inverse variance weighted	23	-0.0060937	0.0390153	0.8758862
Simple mode	23	-0.1399218	0.1186400	0.2508436
Weighted mode	23	-0.1507730	0.1122575	0.1929326

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.93171	21	0.6533219
Inverse variance weighted	17.99133	22	0.7065023

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013777	0.0056423	0.8094633

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005459	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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