Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 798)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0155799 0.1045519 0.8829628
Weighted median 23 -0.0191371 0.0547575 0.7267229
Inverse variance weighted 23 -0.0348517 0.0399637 0.3831629
Simple mode 23 -0.1588436 0.0969113 0.1154236
Weighted mode 23 -0.0149228 0.0623339 0.8130113

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.03794 21 0.3419588
Inverse variance weighted 23.08194 22 0.3971153

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0011835 0.0059098 0.8432055

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007236 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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