Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 797)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0289316	0.0998210	0.7747851
Weighted median	23	0.0727448	0.0559579	0.1936037
Inverse variance weighted	23	0.0164774	0.0390156	0.6727844
Simple mode	23	-0.0179125	0.0918423	0.8471554
Weighted mode	23	0.0270607	0.0690385	0.6988545

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.18162	21	0.5097846
Inverse variance weighted	20.19999	22	0.5705311

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007648	0.0056424	0.8934699

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006175	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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