Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 796)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0429552	0.1037118	0.6829435
Weighted median	23	0.0011360	0.0593250	0.9847219
Inverse variance weighted	23	0.0137800	0.0399363	0.7300573
Simple mode	23	-0.0517552	0.1041614	0.6242062
Weighted mode	23	-0.0616854	0.0892672	0.4967803

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.6695	21	0.3618501
Inverse variance weighted	23.0508	22	0.3988659

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034841	0.0058623	0.5586444

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007023	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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