Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 795)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0720596	0.0998197	0.4783194
Weighted median	23	0.0113194	0.0561654	0.8402792
Inverse variance weighted	23	-0.0072221	0.0390153	0.8531435
Simple mode	23	0.0366744	0.1031879	0.7256648
Weighted mode	23	0.0202885	0.0794057	0.8007071

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.08801	21	0.6434278
Inverse variance weighted	18.58600	22	0.6707342

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039817	0.0056423	0.4881407

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005642	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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