Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 794)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1137856	0.0998201	0.2671600
Weighted median	23	0.0529346	0.0554511	0.3397706
Inverse variance weighted	23	0.0644503	0.0390155	0.0985519
Simple mode	23	0.0083983	0.0988462	0.9330590
Weighted mode	23	0.0580832	0.0659902	0.3882759

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.14066	21	0.6400865
Inverse variance weighted	18.42898	22	0.6802728

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030297	0.0056423	0.5969409

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006411	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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