Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 793)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0719522	0.0998208	0.4789721
Weighted median	23	0.0719306	0.0539051	0.1820745
Inverse variance weighted	23	0.0533464	0.0390158	0.1715309
Simple mode	23	0.0376871	0.0851919	0.6625335
Weighted mode	23	0.0636592	0.0614437	0.3114297

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.35121	21	0.9296474
Inverse variance weighted	12.39222	22	0.9487414

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011426	0.0056424	0.8414739

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004322	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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