Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 792)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0363826	0.0998205	0.7191440
Weighted median	23	-0.0448741	0.0534927	0.4015351
Inverse variance weighted	23	-0.0360858	0.0390157	0.3550146
Simple mode	23	-0.1069765	0.0934517	0.2646248
Weighted mode	23	-0.0391771	0.0640322	0.5469191

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.12579	21	0.5133065
Inverse variance weighted	20.12580	22	0.5751708

Test for directional horizontal pleiotropy

egger_intercept	se	pval
1.82e-05	0.0056423	0.9974535

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006358	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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