Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 791)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0510331	0.0998209	0.6145118
Weighted median	23	0.0125028	0.0545215	0.8186210
Inverse variance weighted	23	0.0418588	0.0390158	0.2833300
Simple mode	23	0.0199710	0.0925488	0.8311408
Weighted mode	23	0.0199710	0.0684915	0.7733372

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.71179	21	0.7284221
Inverse variance weighted	16.72176	22	0.7785255

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005634	0.0056423	0.9214099

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005416	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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