Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 790)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0655291	0.0998200	0.5186499
Weighted median	23	0.0468682	0.0548116	0.3925085
Inverse variance weighted	23	0.0350751	0.0390156	0.3686521
Simple mode	23	-0.0410612	0.0952517	0.6706038
Weighted mode	23	0.0740647	0.0679010	0.2871747

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.76449	21	0.7827342
Inverse variance weighted	15.87435	22	0.8220724

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018702	0.0056423	0.743585

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005055	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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